Overview  Getting to a polycythemia vera diagnosis is less about one “magic” test and more about a consistent picture. Doctors look for elevated hemoglobin or hematocrit on a complete blood count, assess whether the […]

Overview  The JAK-STAT pathway relays growth signals from the cell surface to the nucleus: a cytokine binds its receptor, JAK is activated, STAT is phosphorylated, dimerizes, and activates target genes. In […]

Overview  Polycythemia vera is driven, in most people, by a change in a signaling protein called JAK2. That change can keep blood cell production “on,” which contributes to thicker blood […]